Probiotic effect of Lactococcus lactis subsp. cremoris RPG-HL-0136 on intestinal mucosal immunity in mice

Abstract Lactococcus lactis subsp . cremoris is a lactic acid bacterium commonly used in the cheese manufacturing industry. It known to produce antibacterial peptides and has recently received attention for its role as probiotic strain. Here, we report isolation of new strain, RPG-HL-0136 (RPG0136) from dried compost, which exhibits strong activity. When RPG0136 was fed mice, it increased intestinal population two beneficial bacteria, Lactobacillus Bifidobacterium , whereas decreased harmful Bacteroides Enterobacter In addition, concentration short-chain fatty acids, including acetic acid, propionic butyric with simultaneous decrease pH, accelerated catabolic degradation proteins, lipids, starch. Lastly, plasma IgG mucosal SIgA concentrations upregulated Reg3r, MUC1, MUC2 expression improve immune function. The results this study suggest that potential strain supports growth microbiome by promoting synthesis organic acids enhancing